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Review 2: "A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants"

This preprint examines lipid droplet plasticity as a feature of infection that can be stopped by glycolipid biosynthesis inhibitors and finds that they are a host dependency factor supporting COVID-19. Reviewers found this study reliable and informative for virus evolution.

Published onMar 30, 2022
Review 2: "A global lipid map reveals host dependency factors conserved across SARS-CoV-2 variants"

RR:C19 Evidence Scale rating by reviewer:

  • Reliable. The main study claims are generally justified by its methods and data. The results and conclusions are likely to be similar to the hypothetical ideal study. There are some minor caveats or limitations, but they would/do not change the major claims of the study. The study provides sufficient strength of evidence on its own that its main claims should be considered actionable, with some room for future revision.

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Review:

Very interesting work. This is an important aspect of virology that adds a new dimension to the existing literature. This will help our understanding of Sars-CoV-2 as well as other viral infections and their effect. on host cells.

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