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Review of "Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway"

Reviewer: Alina Chan (Broad Institute) | 📗📗📗📗◻️

Published onMar 24, 2022
Review of "Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway"
key-enterThis Pub is a Review of
Mutations that adapt SARS-CoV-2 to mustelid hosts do not increase fitness in the human airway
Description

AbstractSARS-CoV-2 has a broad mammalian species tropism infecting humans, cats, dogs and farmed mink. Since the start of the 2019 pandemic several reverse zoonotic outbreaks of SARS-CoV-2 have occurred in mink, one of which reinfected humans and caused a cluster of infections in Denmark. Here we investigate the molecular basis of mink and ferret adaptation and demonstrate the spike mutations Y453F, F486L, and N501T all specifically adapt SARS-CoV-2 to use mustelid ACE2. Furthermore, we risk assess these mutations and conclude mink-adapted viruses are unlikely to pose an increased threat to humans, as Y453F attenuates the virus replication in human cells and all 3 mink-adaptations have minimal antigenic impact. Finally, we show that certain SARS-CoV-2 variants emerging from circulation in humans may naturally have a greater propensity to infect mustelid hosts and therefore these species should continue to be surveyed for reverse zoonotic infections.

To read the original manuscript, click the link above.

Since our solicitation of reviews, this preprint has been published in Cell journal and the link to the published manuscript can be found here.

Reviewer 1 (Alina Chan) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the review, click the link below. 

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