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Reviews of "SARS-CoV-2 Can Infect Human Embryos"

Reviewers: Giovanni Piedimonte (Tulane University) | 📒📒📒 ◻️◻️ • Rana Chakraborty (Mayo Clinic) | 📒📒📒◻️◻️

Published onMay 24, 2022
Reviews of "SARS-CoV-2 Can Infect Human Embryos"
key-enterThis Pub is a Review of
SARS-CoV-2 Can Infect Human Embryos
Description

AbstractThe spread of SARS-CoV-2 has led to a devastating pandemic, with infections resulting in a range of symptoms collectively known as COVID-19. The full repertoire of human tissues and organs susceptible to infection is an area of active investigation, and some studies have implicated the reproductive system. The effects of COVID-19 on human reproduction remain poorly understood, and particularly the impact on early embryogenesis and establishment of a pregnancy are not known. In this work, we explore the susceptibility of early human embryos to SARS-CoV-2 infection. We note that ACE2 and TMPRSS2, two canonical cell entry factors for SARS-CoV-2, are co-expressed in cells of the trophectoderm in blastocyst-stage preimplantation embryos. Using fluorescent reporter virions pseudotyped with Spike (S) glycoprotein from SARS-CoV-2, we observe robust infection of trophectoderm cells, and this permissiveness could be attenuated with blocking antibodies targeting S or ACE2. When exposing human blastocysts to the live, fully infectious SARS-CoV-2, we detected cases of infection that compromised embryo health. Therefore, we identify a new human target tissue for SARS-CoV-2 with potential medical implications for reproductive health during the COVID-19 pandemic and its aftermath.

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Summary of Reviews: This study seeks to examine the susceptibility of early human embryos to SARS-CoV-2 infection. Although the reviewers find conclusions well substantiated by the experiments, they also find the practical relevance of the study limited, and not in line with epidemiologic data.

Reviewer 1 (Giovanni Piedimonte) | 📒📒📒 ◻️◻️

Reviewer 2 (Rana Chakraborty) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below.


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