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Reviews of "Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses"

Reviewers: Sarah Stanley, Scott Biering (UC Berkeley) | 📗📗📗📗 ◻️ • Saumendra N. Sarkar (University of Pittsburgh) | 📗📗📗📗 ◻️

Published onAug 26, 2020
Reviews of "Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses"
key-enterThis Pub is a Review of
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Anti-SARS-CoV-2 IgG from severely ill COVID-19 patients promotes macrophage hyper-inflammatory responses
Description

Abstract For yet unknown reasons, severely ill COVID-19 patients often become critically ill around the time of activation of adaptive immunity. Here, we show that anti-Spike IgG from serum of severely ill COVID-19 patients induces a hyper-inflammatory response by human macrophages, which subsequently breaks pulmonary endothelial barrier integrity and induces microvascular thrombosis. The excessive inflammatory capacity of this anti-Spike IgG is related to glycosylation changes in the IgG Fc tail. Moreover, the hyper-inflammatory response induced by anti-Spike IgG can be specifically counteracted in vitro by use of the active component of fostamatinib, an FDA- and EMA-approved therapeutic small molecule inhibitor of Syk.One sentence summary Anti-Spike IgG promotes hyper-inflammation.

To read the original manuscript, click the link above.

Summary of Reviews: This study introduces a novel therapeutic approach to treating COVID-19. Study motivates further investigation of whether selectively inhibiting FcR receptor driven inflammation could result in more targeted and effective COVID-19 interventions.

Reviewer 1 (Sarah Stanley, Scott Biering) | 📗📗📗📗◻️

Reviewer 2 (Saumendra N. Sarkar) | 📗📗📗📗 ◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

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