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Reviews: "Factors Driving Extensive Spatial and Temporal Fluctuations in COVID-19 Fatality Rates in Brazilian Hospitals"

Reviewers: F Benita (Singapore University of Technology and Design) | 📗📗📗📗◻️ • M Boufadel (New Jersey Institute of Technology) | 📗📗📗📗◻️

Published onJan 26, 2022
Reviews: "Factors Driving Extensive Spatial and Temporal Fluctuations in COVID-19 Fatality Rates in Brazilian Hospitals"
key-enterThis Pub is a Review of
Report 46: Factors driving extensive spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals
Description

AbstractThe SARS-CoV-2 Gamma variant spread rapidly across Brazil, causing substantial infection and death waves. We use individual-level patient records following hospitalisation with suspected or confirmed COVID-19 to document the extensive shocks in hospital fatality rates that followed Gamma’s spread across 14 state capitals, and in which more than half of hospitalised patients died over sustained time periods. We show that extensive fluctuations in COVID-19 in-hospital fatality rates also existed prior to Gamma’s detection, and were largely transient after Gamma’s detection, subsiding with hospital demand. Using a Bayesian fatality rate model, we find that the geographic and temporal fluctuations in Brazil’s COVID-19 in-hospital fatality rates are primarily associated with geographic inequities and shortages in healthcare capacity. We project that approximately half of Brazil’s COVID-19 deaths in hospitals could have been avoided without pre-pandemic geographic inequities and without pandemic healthcare pressure. Our results suggest that investments in healthcare resources, healthcare optimization, and pandemic preparedness are critical to minimize population wide mortality and morbidity caused by highly transmissible and deadly pathogens such as SARS-CoV-2, especially in low- and middle-income countries.NoteThe following manuscript has appeared as ‘Report 46 - Factors driving extensive spatial and temporal fluctuations in COVID-19 fatality rates in Brazilian hospitals’ at https://spiral.imperial.ac.uk:8443/handle/10044/1/91875.One sentence summaryCOVID-19 in-hospital fatality rates fluctuate dramatically in Brazil, and these fluctuations are primarily associated with geographic inequities and shortages in healthcare capacity.

To read the original manuscript, click the link above.

Summary of Reviews: This study focuses on the rising fatality rate of COVID-19 Gamma variant in Brazilian hospitals. The data reveals that the increasing fatalities are explained by changes in healthcare pressures rather than the Gamma variant itself.

Reviewer 1 (Francisco B…) | 📗📗📗📗◻️

Reviewer 2 (Michel B…) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

To read the reviews, click the links below. 


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