Skip to main content
SearchLoginLogin or Signup

Reviews of "Viral Variants and Vaccinations: If We Can Change the COVID-19 Vaccine, Should We?"

Reviewer: D Reeves (Fred Hutchinson Cancer Research Center) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ

Published onMar 31, 2022
Reviews of "Viral Variants and Vaccinations: If We Can Change the COVID-19 Vaccine, Should We?"
key-enterThis Pub is a Review of
Viral Variants and Vaccinations: If We Can Change the COVID-19 Vaccineโ€ฆ Should We?
Description

AbstractAs we close in on one year since the COVID-19 pandemic began, hope has been placed on bringing the virus under control through mass administration of recently developed vaccines. Unfortunately, newly emerged, fast-spreading strains of COVID-19 threaten to undermine progress by interfering with vaccine efficacy. While a long-term solution to this challenge would be to develop vaccines that simultaneously target multiple different COVID-19 variants, this approach faces both developmental and regulatory hurdles. A simpler option would be to switch the target of the current vaccine to better match the newest viral variant. I use a stochastic simulation to determine when it is better to target a newly emerged viral variant and when it is better to target the dominant but potentially less transmissible strain. My simulation results suggest that it is almost always better to target the faster spreading strain, even when the initial prevalence of this variant is much lower. In scenarios where targeting the slower spreading variant is best, all vaccination strategies perform relatively well, meaning that the choice of vaccination strategy has a small effect on public health outcomes. In scenarios where targeting the faster spreading variant is best, use of vaccines against the faster spreading viral variant can save many lives. My results provide โ€˜rule of thumbโ€™ guidance for those making critical decisions about vaccine formulation over the coming months.

To read the original manuscript, click the link above.

Reviewer 1 (Daniel Rโ€ฆ) | ๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ

RR:C19 Strength of Evidence Scale Key

๐Ÿ“• โ—ป๏ธโ—ป๏ธโ—ป๏ธโ—ป๏ธ = Misleading

๐Ÿ“™๐Ÿ“™ โ—ป๏ธโ—ป๏ธโ—ป๏ธ = Not Informative

๐Ÿ“’๐Ÿ“’๐Ÿ“’ โ—ป๏ธโ—ป๏ธ = Potentially Informative

๐Ÿ“—๐Ÿ“—๐Ÿ“—๐Ÿ“—โ—ป๏ธ = Reliable

๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜๐Ÿ“˜ = Strong

To read the reviews, click the links below.ย 


Comments
1
?
James Robrt:

Finally, consider tires that are specifically designed for all-terrain use. All-terrain tires are designed to provide superior traction in a variety of conditions. They are also designed to provide better stability and greater overall performance in off-road applications.
https://bestallterraintires.com/best-265-75r16-all-terrain-tires/

?
Lynn Davenport:

In free games, you can unlock new colors, figures, settings, and a lot more.