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Reviews of "Serum Sphingosine-1-Phosphate as Novel Prognostic and Predictive Biomarker for COVID-19 Severity and Morbidity and Its Implications in Clinical Management"

Reviewers: Yoh Takuwa (Kanazawa University) | 📒📒📒◻️◻️ • Hideru Obinata (Gunma University) | 📒📒📒◻️◻️ • Markus Gräler (Jena University Hospital) | 📙📙◻️◻️◻️ • Georgios Grammatikos (Goethe University Frankfurt) | 📒📒📒◻️◻️

Published onSep 22, 2020
Reviews of "Serum Sphingosine-1-Phosphate as Novel Prognostic and Predictive Biomarker for COVID-19 Severity and Morbidity and Its Implications in Clinical Management"

To read the original manuscript, click the link above.

Summary of Reviews: This potentially informative article with some methodological flaws suggests that serum Sphingosine-1-Phosphate (S1P) is associated with COVID-19 severity. Further research is needed to understand if serum S1P could be provided therapeutically to reduce COVID-19 severity.

Reviewer 1 (Yoh Takuwa) | 📒📒📒◻️◻️

Reviewer 2 (Hideru Obinata) | 📒📒📒 ◻️◻️

Reviewer 3 (Markus Gräler) | 📙📙 ◻️◻️◻️

Reviewer 4 (Georgios Grammatikos) | 📒📒📒 ◻️◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

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