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Reviews of "IL-6 and IL-10 as predictors of disease severity in COVID 19 patients: Results from Meta-analysis and Regression"

Reviewers: You-Wen He (Duke University Medical Center) | 📘📘📘📘📘 • Tsvetelina Velikova (University Hospital Lozenetz) | 📗📗📗📗◻️

Published onSep 30, 2020
Reviews of "IL-6 and IL-10 as predictors of disease severity in COVID 19 patients: Results from Meta-analysis and Regression"
key-enterThis Pub is a Review of
IL-6 and IL-10 as predictors of disease severity in COVID 19 patients: Results from Meta-analysis and Regression
Description

Aims: SARS-CoV-2, an infectious agent behind the ongoing COVID-19 pandemic, induces high levels of cytokines such as IL-1, IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ etc in infected individuals which contribute towards the underlying disease patho-physiology. Nonetheless, exact association and contribution of every cytokine towards COVID-19 pathology remains poorly understood. Delineation of the role of the cytokines during COVID-19 holds the key of efficient patient management in clinics. This study performed a comprehensive meta-analysis to establish association between induced cytokines and COVID-19 disease severity to help in prognosis and clinical care. Main methods: Scientific literature was searched to identify 13 cytokines (IL-1β, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-17, TNF-α and IFN-γ) from 18 clinical studies. Standardized mean difference (SMD) for selected 6 cytokines IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ between severe and non-severe COVID-19 patient groups were summarized using random effects model. A classifier was built using logistic regression model with cytokines having significant SMD as covariates. Key findings: Out of 13 cytokines, IL-6 and IL-10 showed statistically significant SMD across the studies synthesized. Classifier with mean values of both IL-6 and IL-10 as covariates performed well with accuracy of ~ 92% that was significantly higher than accuracy reported in literature with IL-6 and IL-10 as individual covariates. Significance: Simple panel proposed by us with only two cytokine markers can be used as predictors for fast diagnosis of patients with higher risk of COVID-19 disease deterioration and thus can be managed well for a favourable prognosis.

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Summary of Reviews: This pre-print says that higher levels of cytokines IL-6 and IL-10 are associated with increased severity of COVID-19. Reviewer consensus suggests this well-conducted study provides scientific evidence of potential prognostic markers that could be useful in clinical care.

Reviewer 1 (You-Wen He) | 📘📘📘📘📘

Reviewer 2 (Tsvetelina Velikova) | 📗📗📗📗◻️

RR:C19 Strength of Evidence Scale Key

📕 ◻️◻️◻️◻️ = Misleading

📙📙 ◻️◻️◻️ = Not Informative

📒📒📒 ◻️◻️ = Potentially Informative

📗📗📗📗◻️ = Reliable

📘📘📘📘📘 = Strong

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